Lysophosphatidylinositol Signalling and Metabolic Diseases

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Lysophosphatidylinositol Signalling and Metabolic Diseases.

Metabolism is a chemical process used by cells to transform food-derived nutrients, such as proteins, carbohydrates and fats, into chemical and thermal energy. Whenever an alteration of this process occurs, the chemical balance within the cells is impaired and this can affect their growth and response to the environment, leading to the development of a metabolic disease. Metabolic syndrome, a c...

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GPR55-dependent and -independent ion signalling in response to lysophosphatidylinositol in endothelial cells

BACKGROUND AND PURPOSE The glycerol-based lysophospholipid lysophosphatidylinositol (LPI) is an endogenous agonist of the G-protein-coupled receptor 55 (GPR55) exhibiting cannabinoid receptor-like properties in endothelial cells. To estimate the contribution of GPR55 to the physiological effects of LPI, the GPR55-dependent and -independent electrical responses in this cell type were investigate...

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RESEARCH PAPER: GPR55dependent and independent ion signalling in response to lysophosphatidylinositol in endothelial cells

Background and purpose: The glycerol-based lysophospholipid lysophosphatidylinositol (LPI) is an endogenous agonist of the G-protein-coupled receptor 55 (GPR55) exhibiting cannabinoid receptor-like properties in endothelial cells. To estimate the contribution of GPR55 to the physiological effects of LPI, the GPR55-dependent and -independent electrical responses in this cell type were investigat...

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School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK; Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, UK; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, CH-3012, Bern, Switzerland; Departments of Behavioral Sciences & Molecular Biology, Ar...

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ژورنال

عنوان ژورنال: Metabolites

سال: 2016

ISSN: 2218-1989

DOI: 10.3390/metabo6010006